Chronic allograft nephropathy—a model of impaired repair from injury?
نویسندگان
چکیده
منابع مشابه
Computational Biology: Modeling Chronic Renal Allograft Injury
New approaches are needed to develop more effective interventions to prevent long-term rejection of organ allografts. Computational biology provides a powerful tool to assess the large amount of complex data that is generated in longitudinal studies in this area. This manuscript outlines how our two groups are using mathematical modeling to analyze predictors of graft loss using both clinical a...
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The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between genetically identical twins and therefore immunosuppression was not necessary in this particular case (Merrill et al., 1956). However, solid-organ...
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Human Leukocyte Antigens (HLA) (donor-specific anti-HLA antibodies, DSA). Circulating DSA detected after implantation of the donor transplanted organ [de novo immunoglobulin G (IgG) DSA(dnDSA)] are now thought to be the major cause of allograft loss [14,15]. In the last 15 years, the body of knowledge on DSA has grown dramatically [14-34]. In the beginning, the research focused on the associati...
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Short and long term outcome of renal transplantation are determined by acute and chronic rejection processes. In acute transplant rejection, expression of chemokines occurs in different renal compartments where it is triggered through various stimuli e.g. brain death, ischemia, reperfusion, and HLA-mismatch. The induction of chemokine expression precedes the process of organ recovery and extend...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2000
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/15.2.149